Asymmetric Membrane Capsules for Extended Delivery of the Weakly Basic Drug Carvedilol
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چکیده
منابع مشابه
Asymmetric Membrane Capsules for Extended Delivery of the Weakly Basic Drug Carvedilol
The objective of this study was to demonstrate that asymmetric membrane capsules can be used to deliver a poorly water soluble drug with a pH dependent solubility, such as carvedilol, for extended periods of time by modulating solubility with acid. In this study, the effect of the concentration of pH regulating agent and osmotic agents on the release rate of the active material was investigated...
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The aim of the present study was to design an asymmetric membrane capsule, an osmotic pump-based drug delivery system of ethyl cellulose for controlled release of terbutaline sulphate. asymmetric membrane capsules contains pore-forming water soluble additive, sorbitol in different concentrations in the capsule shell membrane, which after coming in contact with water, dissolves, resulting in an ...
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The aim of the present investigation is to develop and statistically optimize the osmotically controlled asymmetric membrane capsules of solid dispersion of lycopene. Solid dispersions of lycopene with β-cyclodextrin in different ratios were prepared using solvent evaporation method. Solubility studies showed that the solid dispersion with 1 : 5 (lycopene : β-cyclodextrin) exhibited optimum sol...
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ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2010
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics2020199